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Title Details:
ACUTE MYELOBLASTIC LEUKEMIA
Authors: Loukopoulos, Dimitris
Reviewer: Konstantopoulos, Konstantinos
Subject: MEDICINE AND HEALTH SCIENCES, LIFE SCIENCES, BIOLOGICAL SCIENCES > HEALTH SCIENCES > MEDICINE > CLINICAL MEDICINE
MEDICINE AND HEALTH SCIENCES, LIFE SCIENCES, BIOLOGICAL SCIENCES > HEALTH SCIENCES
MEDICINE AND HEALTH SCIENCES, LIFE SCIENCES, BIOLOGICAL SCIENCES > HEALTH SCIENCES > MEDICINE > PATHOLOGY
Keywords:
Hematology
Hemostasis
Transfusion Medicine
Biology
Description:
Abstract:
Acute myeloid leukemia denotes an abnormal and uncontrolled proliferation of the myeloid stem cells with a varying degree of inhibition of their differentiation after the stage of blasts and promyelocytes. As a rule, AML is caused by abnormal super-activation of various “proliferation genes” (or inhibition of other “controlling” genes) by products of mutant genes or hybrid genes formed by chromosomal translocations. The leukemic cells invade the marrow and the peripheral blood and finally infiltrate the tissues and organs causing their dysfunction and death. AML presents in various forms, which are further categorized on the basis of specific morphological, or caryotypic or molecular criteria. Immediate therapy is imperative and comprises the administration of the appropriate cytostatic agents along with intensive support with blood products and antibiotics. If the patient is left with no therapy, death within 4-8 weeks is unavoidable. In selected cases cure can be obtained by allogeneic stem cell transplantation.
Table of Contents:
Εισαγωγή
Οξεία λευχαιμία
Σύνοψη
ΜΕΡΟΣ ΠΡΩΤΟ. ΒΑΣΙΚΕΣ ΠΛΗΡΟΦΟΡΙΕΣ
Οξεία μυελοβλαστική λευχαιμία
Κατάταξη
Σύνοψη
Ορισμός. Κατάταξη
Αιτιολογία
Παθολογική Φυσιολογία
Κλινική εικόνα
Εργαστηριακά ευρήματα
Αιματολογικές παράμετροι. Μυελός
Καρυότυπος
Μοριακά ευρήματα
Πρόγνωση
Θεραπεία
Οξεία προμυελοκυτταρική λευχαιμία
ΜΕΡΟΣ ΔΕΥΤΕΡΟ. ΣΥΜΠΛΗΡΩΜΑΤΙΚΕΣ ΠΛΗΡΟΦΟΡΙΕΣ
Ταξινόμηση ΟΜΛ από Παγκόσμιο Οργανισμό Υγείας (2008)
Κυτταρογενετικά ευρήματα στην OMΛ με σημασία για την πρόγνωση
Μοριακά ευρήματα στην ΟΜΛ με σημασία για την πρόγνωση
Παθογένεια της ΟΜΛ
Linguistic Editors: Klada, Nektaria
Graphic Editors: Papakosmas, Ioannis
Type: Chapter
Creation Date: 2015
Item Details:
License: http://creativecommons.org/licenses/by-nc-sa/3.0/gr
Handle http://hdl.handle.net/11419/3096
Bibliographic Reference: Loukopoulos, D. (2015). ACUTE MYELOBLASTIC LEUKEMIA [Chapter]. In Loukopoulos, D., & Politi, M. 2015. HEMATOLOGY LESSONS [Undergraduate textbook]. Kallipos, Open Academic Editions. https://hdl.handle.net/11419/3096
Language: Greek
Is Part of: HEMATOLOGY LESSONS
Number of pages 12
Publication Origin: Kallipos, Open Academic Editions